Bisphosphonates for treatment of osteoporosis

Osteoporosis is a dangerous pathology in which bone tissue lose their mass, become porous, fragile and susceptible to fractures even with minor injuries. The risk of developing this terrible disease is great in the elderly, especially in women. The «gold standard» therapy for osteoporosis are drugs from the group of bisphosphonates.

Comparison of healthy and diseased bone

What is bisphosphonates

It is synthesized analogues of natural substances in the human body which provide strength to bones. Bisphosphonates in the treatment of osteoporosis helps to prevent the loss of calcium. Derivatives of phosphonic acids, selectively acting only on bone, increase in them the contents. By calcium ions in the structure of the skeleton, they give him resistance to deformation.

These drugs from osteoporosis are widely used in the treatment of breast cancer, tumor growths of myeloma, some kinds of lymphoma and other cancers in which the structure of bone tissue breaks. Doctors prescribe their admission and patients with hyperthyroidism, Paget’s disease, when bone is gradually deformed.

The group of bisphosphonates includes drugs that are divided into two large subgroups: those containing and not containing nitrogen. Nitrogen-free compounds are drugs of the first generation: tiludronate, etidronate and sodium clodronate. Tiludronate and etidronate sodium contribute to the saturation of bone calcium and are often used as an alternative to hormonal preparations. Clodronate sodium prevents the metastatic spread. However, the greatest demand compounds containing nitrogen.


Used drugs for osteoporosis

In modern medical practice is especially widely used these medicines:

  • «Alendronova acid», «Tavaron» (drugs of the second generation) – activate in bone metabolism, strengthen the cell structure of patients of both sexes.
  • «Bonviva», «Bondronat» (third generation drugs) to counteract the destruction of bone cells, reduce the risk of fractures in older women.
  • «Zometa» (preparation of the third generation) – significantly inhibits the loss of calcium from bones, has anti-cancer effects.

Bisphosphonates cannot be used in renal failure. Long-term use of such medications increases the risk of serious side effects, particularly with intravenous injection. Possible headaches and joint pain, muscle cramps, malaise, tachycardia, digestive disorders, skin rashes and even necrosis of the jaw bone.

It is important that the use of bisphosphonates to treat osteoporosis were literate, then they are safe. Because medications are absorbed in the lining of the stomach with difficulty, to take them on an empty stomach should be half an hour before eating, with water only. Then you need to stay upright for about 1 hour. If a combination drug, calcium and vitamin D, you can drink only 2 hours after bisphosphonates. Do not confuse these medications with vitamin and mineral supplements. Bisphosphonates – the potent drugs, self-treatment them is unacceptable.

Video about bisphosphonate for the treatment of osteoporosis


Olga, 26 years: my grandmother had bone metastases. Her after irradiation has appointed a cure for osteoporosis «zometa», the analysis showed that the growth of tumor cells is slowed down. It is a pity that the drug all the time makes her nauseous.

Anna, 52 years: the Efficacy of bisphosphonates in the treatment of osteoporosis is marked by all the doctors to whom I spoke. Only need to adhere strictly to the dosage, otherwise you can earn serious complications.

Marina, 29 years: Our mother after a hip fracture, took a long time remedy for osteoporosis «Alendronova acid». Indeed, it is slowly but surely strengthens bones. Too bad that this acid causes indigestion.

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